Phenotypic Categorization of mRNAs Which are Regulated With the Cell Cycle
Early G1
cell cycle regulators
YDL179w PCL9 cyclin like protein interacting with Pho85p
YLR079w SIC1 p40 inhibitor of Cdc28p-Clb protein kinase complex
YER111c SWI4 activates late-G1 specific genes
chromosome, nuclear segregation
none
budding, directional growth
YBR200w BEM1 defect in cellular polarization
DNA replication
YJL194w CDC6 cell division control protein
YLR274w CDC46 member of the Cdc46p/Mcm2p/Mcm3p family
YBR202w CDC47 member of the Cdc46p/Mcm2p/Mcm3p family
YPR019w CDC54 member of the Cdc46p/Mcm2p/Mcm3p family
YBL023c MCM2 member of the Cdc46p/Mcm2p/Mcm3p family
YEL032w MCM3 member of the Cdc46p/Mcm2p/Mcm3p family
DNA repair and recombination
none
transcription factor, unknown phenotype
YGR044c RME1 zinc-finger transcription factor
YML109w ZDS2 multicopy suppressor of sin4
mating pathway
YJL157c FAR1 factor arrest protein
YKL185w ASH1 negative regulator of HO transcription
YHR005c GPA1 GTP-binding protein alpha subunit of the pheromone pathway
glycolysis, respiration
YNR001c CIT1 citrate (si)-synthase, mitochondrial
YKL150w MCR1 cytochrome-b5 reductase
YLR395c COX8 cytochrome-c oxidase chain VIII
YOR065w CYT1 cytochrome-c1
YDL181w INH1 inhibitor of mitochondrial ATPase
YGR183c QCR9 ubiquinol--cytochrome-c reductase subunit 9
YLR258w GSY2 UDP-glucose--starch glucosyltransferase, isoform 2
YML110c COQ5 ubiquinone biosynthesis, methyltransferase
YLR273c PIG1 put.type 1 phosphatase reg.subunit,glycogen defect under
some conditions
YCR005c CIT2 citrate (si)-synthase, peroxisomal
YCL040w GLK1 glucokinase
YMR256c COX7 subunit VII of cytochrome c oxidase
biosynthesis
YIL009w FAA3 acyl CoA synthase
YLL040c VPS13 involved in regulating membrane traffic
YNR016c ACC1 acetyl-CoA carboxylase
miscellaneous
YBR067c TIP1 temperature shock proteinw
YPL058c PDR12 multidrug resistance transporter
YGL055w OLE1 stearoyl-CoA desaturase
YGR281W YOR1 ABC anion transporter
YBR083w TEC1 Ty transcription activator
unknown function
YBR054w YRO2 similarity to HSP30 heat shock protein Yro1p
YKL116c ser/thr protein kinase
YPR002w similarity to B.subtilis mmgE protein
YNR067c similarity to hypothetical protein YLR144c
YBR158w hypothetical protein
YDL117w hypothetical protein
YGR035c hypothetical protein
YHL026c hypothetical protein
YMR007w hypothetical protein
YMR254c hypothetical protein
YNL046w hypothetical protein
YOR264w hypothetical protein
YPL066w VPS28
YBR052c strong similarity to S.pombe brefeldin A resistance protein obr1
YPL158c weak similarity to human nucleolin
YHR022c weak similarity to ras-related protein
YPL004c strong similarity to YGR086c
YBR157c hypothetical protein
YNL078w hypothetical protein
YOR066w hypothetical protein
YMR031c similarity to YKL050c and human restin
YBR053c similarity to rat regucalcin
YDR511w hypothetical protein
YLR254c hypothetical protein
YDR033w strong similarity to putative heat-shock protein YRO2
YKL163w PIR3 protein with internal repeats
YBR231c similarity to human p97 homologous protein
YDR368w YPR1 similar to aldo/keto reductases
YLR050c weak similarity to human MAC30 C-terminus
YLR049c hypothetical protein
YOR273c similarity to resistance proteins
YLR015w hypothetical protein
late G1:
cell cycle regulators
YGR109c CLB6 cyclin, B-type
YPR120c CLB5 cyclin, B-type
YDL127w PCL2 cyclin, G1/S-specific
YNL289w PCL1 cyclin, G1/S-specific
YPL256c CLN2 cyclin, G1/S-specific
YMR199w CLN1 cyclin, G1/S-specific
YJL187c SWE1 phosporylates Cdc28, SPB separation, nuclear division
chromosome, nuclear segregation
YDL003w MCD1 Mitotic Chromosome Determinant
YMR076c PDS5 precocious dissociation of sister chromatids
YKL042w SPC42 spindle pole body component
YFL008w SMC1 chromosome segregation protein
YPL241c CIN2 involved in chromosome segregation
YMR078c CHL12 for chromosome transmission in mitosis and normal telomere
length
YLR212c TUB4 gamma tubulin
YNL225c CNM1 involved in cytokinesis
YPL209c IPL1 ser/thr protein kinase
YJL074c SMC3 required for structural maintenance of chromosomes
budding, directional growth
YNL233w BNI4 bud neck involved
YLR313c SPH1 required for bipolar bud site selection
YGR041w BUD9 budding protein
YGR152c RSR1 GTP-binding protein, affects budding site
YDR507c GIN4 ser/thr protein kinase, affects budding site
YLR286c CTS1 endochitinase
YIL159w BNR1 regulator of budding
YGL027c CWH41 beta 1,6-glucan synthesis
DNA replication
YML102w CAC2 chromatin assembly complex, subunit p60
YPR018w RLF2 chromatin assembly complex, subunit p90
YBL035c POL12 DNA-directed DNA polymerase alpha, 70 KD subunit
YNL102w CDC17 DNA-directed DNA polymerase alpha, 180 KD subunit
YBR278w DPB3 DNA-directed DNA polymerase epsilon,subunit C
YPR175w DPB2 DNA-directed DNA polymerase epsilon, subunit B
YNL262w POL2 DNA-directed DNA polymerase epsilon, subunit A
YBR088c POL30 Proliferating Cell Nuclear Antigen (PCNA)
YLR103c CDC45 required for minichromosome maintenance and init. chr.
replication
YAR007c RFA1 DNA replication factor A, 69 KD subunit
YNL312w RFA2 DNA replication factor A, 36 kDa subunit
YJL173c RFA3 DNA replication factor A, 13 kDa subunit
YER070w RNR1 ribonucleoside-diphosphate reductase, large subunit
YOR074c CDC21 thymidylate synthase
YDL164c CDC9 DNA ligase
YKL045w PRI2 DNA-directed DNA polymerase alpha , 58 KD subunit (DNA primase)"
YBR252w/ DUT1 dUTP pyrophosphorylase
DNA repair and recombination
YLR032w RAD5 DNA helicase
YML060w OGG1 8-oxoguanine DNA glycosylase
YDR097c MSH6 DNA mismatch repair protein
YNL082w PMS1 DNA mismatch repair protein
YOL090w MSH2 DNA mismatch repair protein
YLR383w RHC18 recombination repair protein
YKL113c RAD27 ssDNA endonuclease and 5'-3'exonuclease
YLR234w TOP3 DNA topoisomerase III
YPL153c SPK1 ser/thr/tyr protein kinase, repair checkpoint
YDL101c DUN1 DNA damage response protein kinase
YHR038W KIM4 killed in mutagen
YML021C UNG1 uracil N-glycosylase
YML061c PIF1 mitochondrial DNA repair, 5' to 3' helicase
transcription, unknown/complex phenotype
YMR179w SPT21 required for normal transcription at a number of loci
YML027w YOX1 homoeodomain protein
YPL127c HHO1 histone H1 protein
mating pathway
YGL089c MFAlpha2 mating pheromone alpha-2 factor
YPL187w MFAlpha1 mating pheromone alpha-1 factor
YDL227c HO homothallic switching endonuclease
YNL173c MDG1 GTP-binding protein of the pheromone-response pathway
YLL021w SPA2 forms schmoos poorly
glycolysis and respiration
YLR382c NAM2 respiration deficient. mitochondrial leucyl tRNA synthase
biosynthesis
YJL196c ELO1 fatty acid elongation protein
YJR148w TWT2 branched chain amino acid aminotransferase, cytosolic
YOR317w FAA1 long-chain-fatty-acid CoA ligase
miscellaneous
YKL165c MCD4 sporulation protein
YLL002w KIM2 drug resistance
YPL124w NIP29 nuclear import protein
YKL101w HSL1 ser/thr kinase that interacts with histone mutations and SWE1
YLR457c NBP1 Nap1p-binding protein
YDR297w SUR2 suppressor of rvs161 and rvs167 mutations
YBR070c SAT2 osmotolerance protein
YLR233c EST1 telomere elongation protein
YPL057C/ SUR1 multicopy suppressor of cls2-2, rvs161
YBR073w RDH54 required for meiosis, putative helicase
YGL200c EMP24 component of ER-derived transport vesicles
YHR153c SPO16 early meiotic protein
YNL272C SEC2 secretion defective
YOR316C COT1 sensitivity to cobalt
unknown function
YKR077w hypothetical protein
YDL105w QRI2 protein of unknown function
YPL267w weak similarity to C.elegans transcription factor unc-86
YDL156w weak similarity to Pas7p
YOL017w similarity to YFR013w
YBR071w hypothetical protein
YLL022c hypothetical protein
YLR236c hypothetical protein
YCL022c questionable ORF
YCL024w similarity to ser/thr protein kinase Gin4p
YLR121c strong similarity to aspartylproteases
YHR154w putative DNA damage responsive cell cycle checkpoint protein
YHR110w similarity to human gp25L2 protein
YDL010w similarity to hypothetical protein YBR014c and glutaredoxins
YPR174c weak similarity to Nbp1p
YJL181w similarity to hypothetical protein YJR030c
YLR183c similarity to YDR501w
YOL007c weak similarity to YNL058c
YIL026c IRR1 essential protein
YJR043c hypothetical protein
YKL108w hypothetical protein
YLR326w hypothetical protein
YLR381w hypothetical protein
YNL273w hypothetical protein
YPL014w hypothetical protein
YJL018w questionable ORF
YBR089w questionable ORF
YLR349w questionable ORF
YCL061c hypothetical protein
YDR309c similarity to hypothetical protein YHR061c
YKR013w PRY2 homology to the plant PR-1 class of pathogen related proteins
YJL078c PRY3 contains homology to the plant PR-1 class of pathogen related
proteins
YKL161c strong similarity to ser/thr-specific protein kinase Slt2p
YDL018c weak similarity to Dep1p
YKR083c weak similarity to S.japonicum paramyosin
YDR383c weak similarity to S.pombe paramyosin
YDR013w similarity to human hypothetical KIAA0186 protein
YGR238c KEL2 strong similarity to hypothetical protein YHR158c
YHR113w similarity to vacuolar aminopeptidase Ape1p
YDL119c similarity to bovine Graves disease carrier protein
YDL124w similarity to aldose reductases
YHR039c similarity to aldehyde dehydrogenases
YDR493w hypothetical protein
YNL309w STB1 Sin3p binding protein
YPL208w similarity to YHL039w
YLR376c hypothetical protein
YNL300w hypothetical protein
YAR003W similarity to human RB protein binding protein
YCL060c orf not regarded
YDL103c QRI1 strong similarity to human antigen AgX-1
YGL028c similarity to hypothetical proteins YGR279c, YMR305c
YNL303w hypothetical protein
YNL310c similarity to S. pombe hypothetical protein SPAC24H6.02c
YOR144c weak similarity to human DNA-binding protein PO-GA
S phase:
cell cycle regulators
none
chromosome, nuclear segregation
YDR113c PDS1 cell cycle regulator, chromosome separation
YNL126w SPC98 spindle pole body component
YEL061c CIN8 kinesin-related protein
YHR172w SPC97 spindle pole body component
YPR141c KAR3 kinesin-related protein
YLR045c STU2 suppressor of a cs tubulin mutation
YGR140w CBF2 kinetochore protein complex CBF3, 110 KD subunit
YBL063w KIP1 kinesin-related protein
YDR488c PAC11 required in the absence of Cin8p
YMR198w CIK1 spindle pole body associated protein
YOR026w BUB3 needed for cell cycle arrest when microtubules fail
YDR356w NUF1 spindle pole body component
budding, directional growth
YIL140w SRO4 required for axial pattern of budding
DNA replication
YKL067w YNK1 nucleoside diphosphate kinase
YJR006w HUS2 DNA replication protein, probably the p55 subunit of Pol delta
YBL003c/ HTA2 histone H2A.2
YBL002w/ HTB2 histone H2B.2
DNA repair and recombination
YMR190c SGS1 DNA helicase
transcription, unknown or complex phenotype
YJL115w ASF1 anti-silencing protein
YDL197c ASF2 anti-silencing protein
YCR065w HCM1 transcription factor
YAL001c TFC3 TFIIIC (transcription initiation factor) subunit, 138 kD
YPL016w SWI1 component of SWI/SNF global transcription activator complex
YBL052c SAS3 influences silencing at HMR
YBR275c RIF1 Rap1p interacting factor. telomere silencing
YIL126w STH1 subunit of RSC (chromatin silencing) complex
YFR037c RSC8 subunit of RSC (chromatin silencing) complex
mating pathway
none
glycolysis/respiration
YKL127W/ PGM1 phosphoglycerate mutase
biosynthesis
YAR008w SEN34 tRNA splicing endonuclease gamma subunit
YER001w MNN1 alpha-1,3-mannosyltransferase
YER003c PMI40 mannose-6-phosphate isomerase
YDL093w PMT5 transfers mannose residues in secretory pathway
YIR017c MET28 transcriptional activator of sulfur amino acid metabolism
YKR001c SPO15 vaculole protein sorting, sporulation, deficient
YDL095w PMT1 dolichyl phosphate-D-mannose transferase
YNL073w MSK1 lysyl-tRNA synthetase, mitochondrial
miscellaneous
YER118c SSU81 involved in the HOG1 high-osmolarity signal transduction
pathway
YJR137c ECM17 extracellular mutant, similarity to sulfite reductases
YER017c AFG3 nuclear petite phenotype
YER016w BIM1 binding to microtubules. aberrant MT morphology
YCR035c RRP4 ribosomal RNA processing
unknown function
YOL019w similarity to Rim9p and YFR012w
YLR151c hypothetical protein
YOR284w weak similarity to M.jannaschii hypothetical protein MJ0694
YMR048w hypothetical protein
YKR010c similarity to hypothetical protein YJL076w
YHR061c similarity to hypothetical protein YDR309c
YEL017w hypothetical protein
YLL062c weak similarity to M. leprae metH2 protein
YJR155w strong similarity to aryl-alcohol dehydrogenase
YLR126c weak similarity to P. aeruginosa anthranilate synthase comp. II
YJL118w hypothetical protein
YDR179c hypothetical protein
YDR219c hypothetical protein
YNL176c weak similarity to Hkr1p
YER018c similarity to lamins
YBR156c weak similarity to myosins
YLR455w weak similarity to human G/T mismatch binding protein
YBR184w hypothetical protein
YLR228c strong similarity to YDR213w, weak similarity to Lys14p
YDR252w BTT1 strong similarity to Egd1p and to human Btf3 protein
YNL304w similarity to Ypt1p and other GTP-binding proteins
YGR189C similarity to Utr2p
YAL034W-a hypothetical protein
YBR007c hypothetical protein
YBR276c PPS1 protein phosphatase
YCRX04w unknown function
YDL096c hypothetical protein
YEL018w weak similarity to Rad50p
YER019w hypothetical protein
YFR026C hypothetical protein
YFR027W hypothetical protein
YFR038w strong similarity to mouse lymphocyte specific helicase
YKL066W hypothetical protein
YLL061w strong similarity to amino acid transport protein Gap1p
YNL072W strong similarity to S.pombe hypothetical protein SPAC4G9.02
G2 phase:
cat G2.txt
G2 phase:
cell cycle regulator
YIL050w PCL7 cyclin like protein interacting with Pho85p
chromosome, nuclear segregation
YPR111w DBF20 kinase involved in late nuclear division
YIL106w MOB1 conditional mutants arrest in late mitosis
YBL097w BRN1 chromosome loss in conditional mutants
YKL049c CSE4 required for proper kinetochore function
budding, directional growth
YCL014w BUD3 part of budding protein Bud3p due to frameshift in DNA sequence
YOR188w MSB1 morphogenesis-related protein
YJR076c CDC11 involved in proper bud growth
YJL099w CHS6 chitin biosynthesis
YKL048c ELM1 involved in cell morphology
YBR038w CHS2 chitin synthase II
DNA replication
none
DNA repair and recombination
YJL092w HPR5 ATP-dependent DNA helicase
transcription, unknown or complex phenotype
YCR084c TUP1 mediates glucose repression
mating pathway
none
glycolysis and respiration
none
biosynthesis
YGL255w ZRT1 high-affinity zinc transport protein
YLR014c PPR1 transcription factor regulating pyrimidine pathway
YJL137c GLG2 self-glucosylating initiator of glycogen synthesis
YOR274w MOD5 tRNA isopentenyl transferase
YBR104w YMC2 mitochondrial carrier protein
miscellaneous
YJR112w NNF1 nuclear envelope protein
YCR073c SSK22 MAPKKK, high osmolarity sensitive with SSK2
YDL198c YHM1 suppressor of abf2
YLL046c RNP1 ribonucleoprotein
YDR389w SAC7 suppressor of actin mutation
YDR464w SPP41 regulates spliceosome components
YER069w ARG5,6 acetylglutamate kinase
YKL068w NUP100 nucleocytoplasmic transport
unknown function
YIL131c FKH1 similarity to Drosophila fork head protein
YDR451c strong similarity to Yox1p
YCR085w hypothetical protein
YMR003w hypothetical protein
YNR009w hypothetical protein
YOR073w hypothetical protein
YMR215w similarity to GAS1 protein
YLL047w questionable ORF
YDR366c questionable ORF
YIL158w similarity to hypothetical protein YKR100c
YGL101w strong similarity to hypothetical protein YBR242w
YJR110w similarity to C.elegans hypothetical protein T24A11.1
YOL012c HTZ1 strong similarity to histone H2A proteins
YBL032w weak similarity to hnRNP complex protein homolog YBR233w
YBR043c similarity to benomyl/methotrexate resistance protein
YCL012w part of budding protein Bud3p due to frameshift in DNA sequence
YCL013w ORF not regarded
YCL062w ORF not regarded
YCL063w weak similarity to yeast translation regulator Gcd6p
YCR086w hypothetical protein
YDR324C weak similarity to beta transducin from S. pombe and other WD-40 repeat containing proteins
YDR325W hypothetical protein
YIL169C similarity to glucan 1,4-alpha-glucosidase and YAR066w
YKL052C hypothetical protein
YKL053W similarity to C.elegans hypothetical protein T09A5.7 (12.5 kD)
YKL069W strong similarity to hypothetical E. coli protein b1832
YPL116W HOS3 protein with similarity to Hda1p, Hos2p, Hos1p
YPL264C strong similarity to YMR253c
M phase:
cat M.txt
cell cycle regulators
YGR108w CLB1 cyclin, G2/M-specific
YPR119w CLB2 cyclin, G2/M-specific
YAL040c CLN3 cyclin, G-specific
YGL116w CDC20 cell division control protein
chromosome, nuclear segregation
YOL069w NUF2 spindle pole body protein
YGR092w DBF2 ser/thr protein kinase related to Dbf20p
YBR138c HDR1 high-dosage reductional segregation defective
YOR058c ASE1 microtubule-associated protein
YHR023w MYO1 myosin-1 isoform heavy chain
YPL242C IQG1 defects in cytokinesis, morphology
budding, directional growth
YJR092w BUD4 budding protein
YLR353w BUD8 budding protein
YCL037C SRO9 organizer of actin filaments
DNA replication
YMR001c CDC5 involved in regulation of DNA replication
DNA repair and recombination
YGL021w ALK1 DNA damage-responsive protein
transcription, unknown/complex phenotype
YCR042c TSM1 component of TAF(II) complex
YOR025w HST3 silencing protein
YOR229w WTM2 transcriptional modulator
YDR146c SWI5 transcription factor
YLR131c ACE2 metallothionein expression activator
mating pathway
YNL053w MSG5 dual specificity phosphatase, suppresses GPA1
YKL130C SHE2 required for mother cell-specific expression of HO
glycolysis and respiration
YIL162w SUC2 invertase (sucrose hydrolyzing enzyme)
YDL138W RGT2 suppresses snf3 mutants
biosynthesis
YDL048c STP4 used in pre-tRNA splicing and in uptake of branched-chain
amino acids
YGR143w SKN1 glucan synthase subunit
miscellaneous
YKL129c MYO3 myosin-type I
YIL167w SDL1 serine dehydratase
YHR152w SPO12 used in meiosis I, suppresses DBF2
YPR167C MET16 3' phosphoadenylylsulfate reductase
unknown function
YJL079c PRY1 homology to the plant PR-1 class of pathogen related proteins
YAR018c KIN3 ser/thr protein kinase
YAL022c FUN26 weak similarity to Na+/H+ antiporter
YGR279c strong similarity to YMR305c
YGL201c MCM6 similarity with rat intestinal DNA replication protein
YNL057w questionable ORF
YML119w hypothetical protein
YOL137w weak similarity to tetracycline resistance proteins
YPL186c weak similarity to Xenopus protein xlgv7
YCL038c similarity to bacterial membrane transporter
YML033w similarity to YDR458c
YML034w similarity to YDR458c
YKR021w strong similarity to hypothetical protein YJL084c
YPR157w strong similarity to YGR141w
YJL051w hypothetical protein
YOL014w hypothetical protein
YOR315w hypothetical protein
YGR230w questionable ORF
YLR190w hypothetical protein
YMR032w weak similarity to S.pombe cdc15
YOL070c hypothetical protein
YLR297W weak similarity to Vibrio vulnificus VvpC protein
YHL028W WSC4 putative integral membrane protein
YHR151C hypothetical protein
YNL058C similarity to YIL117c
Multiple Phases:
cell cycle regulators
YBR160w "g1,g2" CDC28 cyclin-dependent kinase
YDL155W "s,g2" CLB3 G2/M cyclin
YLR210W "s,m" CLB4 G2/M cyclin
YOR373W "eg1,s" NUD1 cell cycle regulatory protein
chromosome, nuclear segregation
YDR150w "s,m" NUM1 nuclear migration protein
budding, directional growth
YKL092C/ "eg1,g2" BUD2 GTPase activating protein for Rsr1p
DNA replication
YDR224c/ "lg1,g2" HTB1 histone H2B
YDR225w/ "lg1, g2" HTA1histone H2A
DNA repair and recombination
YKL032c "g2,m" IXR1 intrastrand crosslink recognition protein and
transcription factor
transcription, complex phenotype
none
mating pathway
none
glycolysis, respiration
YDR277c "s,m" MTH1 repressor of hexose transport genes
YJR159w "s,g2" SOR1 sorbitol dehydrogenase
biosynthesis
YML091c "s,m" "RPM2 ribonuclease P precursor, mitochondrial"
miscellaneous
YHR086w "s,g2" NAM8 meiotic recombination protein
unknown function
YJL103c "s,m" putative regulatory protein
YBR065c "s,m" ECM2 similarity to C.elegans hypothetical protein
YMR090w "s,m" hypothetical protein
YPL044c "s,m" questionable ORF
YKR012c "lg1,g2" questionable ORF
YCR034w "eg1,m" "GNS1 probable beta-1,3-glucan synthase subunit and
required for sphingolipid formation"
YER190w "eg1,g2" strong similarity to subtelomeric encoded proteins
YDL031w "eg1,g2" similarity to RNA helicases
YDR094w "eg1,g2" questionable ORF
YMR148w "m,eg1" hypothetical protein
YFR017c "eg1,s" hypothetical protein
YOL155c-S "lg1,s" "similarity to glucan 1,4-alpha-glucosidase Sta1p
and YAR066w"
YJL073w "lg1,s" JEM1 similarity to heat shock proteins
YHR173c "lg1,g2" hypothetical protein
YER032w "s,m" FIR1 interacts with the poly(A) polymerase in the
two-hybrid system
YHR178w "s,m" STB5 SIN3 binding protein
YHR031c "s,g2" similarity to Pif1p
YPL133c "s,m" weak similarity to transcription factors
YGL059w "s,m" similarity to rat branched-chain alpha-ketoacid
dehydrogenase kinase
YLR281c "s,m" similarity to polypeptide chain release factors
YBR268w/ "lg1,g2" MRPL37 probably mitochondrial protein